BSI PD ISO/TR 16197:2014
$167.15
Nanotechnologies. Compilation and description of toxicological screening methods for manufactured nanomaterials
| Published By | Publication Date | Number of Pages |
| BSI | 2014 | 42 |
This Technical Report provides a compilation and description of in vitro and in vivo methods that can be useful for the toxicological, including ecotoxicological screening of engineered and manufactured nanomaterials. Toxicological screening tests included in this Technical Report can be used for such purposes as early decision-making in research and product development, rapid feedback on potential toxicological/safety concerns, or for the preliminary assessment of manufactured nanomaterials. This Technical Report is divided between screening assays related to humans and screening assays related to the environment. A screening test is a relatively simple, inexpensive test that can be administered easily and provides an indication of potential adverse outcomes and effects on human health or the environment.
The Technical Report is intended to complement other international efforts that address nanomaterial toxicology by focusing on screening methods suited for preliminary assessment and is not intended to duplicate similar efforts in other international organizations such as the Organization for Economic Cooperation and Development (OECD). If screening provides an early indication of hazard, the guidance will refer to other organizations’ approaches for full-scale toxicological assessment or further tiered studies.
PDF Catalog
| PDF Pages | PDF Title |
|---|---|
| 6 | Foreword |
| 7 | Introduction |
| 9 | Section sec_1 Section sec_2 Section sec_3 Section sec_3.1 1 Scope 2 Normative references 3 Terms and definitions |
| 10 | Section sec_3.2 Section sec_3.3 Section sec_3.4 Section sec_3.5 Section sec_3.6 Section sec_3.7 |
| 11 | Section sec_3.8 Section sec_3.9 Section sec_3.10 Section sec_4 Section sec_5 Section sec_5.1 4 Symbols (and abbreviated terms) 5 Background 5.1 Role and relevance of toxicological screening for the safety evaluation of manufactured NMs |
| 12 | Section sec_5.2 5.2 Toxicological screening as part of tiered approaches to toxicological assessment of manufactured NMs |
| 13 | Section sec_5.3 5.3 Discussion of relevant dosing for toxicological screening |
| 14 | Section sec_5.4 Section sec_5.5 Section sec_5.6 Table tab_1 5.4 Discussion of the relationship between this Technical Report and ISO/DTR 16196, Compilation and description of sample preparation and dosing methods for manufactured NMs 5.5 Discussion of the relationship between this Technical Report and ISO/TR 13014, Nanotechnologies — Guidance on physico-chemical characterization of engineered nanoscale materials for toxicological assessment 5.6 Review of other relevant international activities and published documents |
| 15 | Table tab_2 Section sec_6 Section sec_6.1 Section sec_6.2 6 Methods for toxicological screening related to human health 6.1 General 6.2 Positive and negative controls for nanomaterial toxicity testing |
| 16 | Section sec_6.3 Section sec_6.3.1 6.3 Relevant methods for in vitro toxicological screening of manufactured NMs |
| 17 | Section sec_6.3.2 Section sec_6.3.3 |
| 20 | Table tab_3 Section sec_6.3.4 Section sec_6.3.4.1 Section sec_6.3.4.2 |
| 21 | Section sec_6.3.4.3 Section sec_6.3.4.3.1 Section sec_6.3.4.3.2 Section sec_6.3.4.3.3 |
| 22 | Section sec_6.3.5 Section sec_6.3.5.1 Section sec_6.3.5.2 Section sec_6.3.5.3 Section sec_6.3.5.4 |
| 23 | Section sec_6.3.6 |
| 24 | Section sec_6.3.7 Section sec_6.3.7.1 Section sec_6.3.7.2 |
| 25 | Section sec_6.3.7.3 |
| 26 | Section sec_6.3.8 Section sec_6.3.9 |
| 27 | Section sec_6.4 Section sec_6.4.1 Section sec_6.4.2 Section sec_6.4.3 6.4 Relevant methods for in vivo toxicological screening of manufactured NMs |
| 28 | Section sec_7 Section sec_7.1 Section sec_7.2 7 Methods for toxicological screening related to the environment 7.1 Introduction 7.2 Environmental fate and distribution |
| 29 | Section sec_7.3 Section sec_7.4 7.3 Environmental degradation and transformation 7.4 Environmental biopersistence and bioaccumulation |
| 30 | Reference ref_1 Reference ref_2 Reference ref_3 Reference ref_4 Reference ref_5 Reference ref_6 Reference ref_7 Reference ref_8 Reference ref_9 Reference ref_10 Reference ref_11 Reference ref_12 Reference ref_13 Reference ref_14 Reference ref_15 Reference ref_16 Reference ref_17 Reference ref_18 Bibliography |
| 31 | Reference ref_19 Reference ref_20 Reference ref_21 Reference ref_22 Reference ref_23 Reference ref_24 Reference ref_25 Reference ref_26 Reference ref_27 Reference ref_28 Reference ref_29 Reference ref_30 Reference ref_31 Reference ref_32 Reference ref_33 Reference ref_34 Reference ref_35 |
| 32 | Reference ref_36 Reference ref_37 Reference ref_38 Reference ref_39 Reference ref_40 Reference ref_41 Reference ref_42 Reference ref_43 Reference ref_44 Reference ref_45 Reference ref_46 Reference ref_47 Reference ref_48 Reference ref_49 Reference ref_50 Reference ref_51 Reference ref_52 |
| 33 | Reference ref_53 Reference ref_54 Reference ref_55 Reference ref_56 Reference ref_57 Reference ref_58 Reference ref_59 Reference ref_60 Reference ref_61 Reference ref_62 Reference ref_63 Reference ref_64 Reference ref_65 Reference ref_66 Reference ref_67 Reference ref_68 Reference ref_69 |
| 34 | Reference ref_70 Reference ref_71 Reference ref_72 Reference ref_73 Reference ref_74 Reference ref_75 Reference ref_76 Reference ref_77 Reference ref_78 Reference ref_79 Reference ref_80 Reference ref_81 Reference ref_82 Reference ref_83 Reference ref_84 Reference ref_85 Reference ref_86 Reference ref_87 |
| 35 | Reference ref_88 Reference ref_89 Reference ref_90 Reference ref_91 Reference ref_92 Reference ref_93 Reference ref_94 Reference ref_95 Reference ref_96 Reference ref_97 Reference ref_98 Reference ref_99 Reference ref_100 Reference ref_101 Reference ref_102 Reference ref_103 Reference ref_104 |
| 36 | Reference ref_105 Reference ref_106 Reference ref_107 Reference ref_108 Reference ref_109 Reference ref_110 Reference ref_111 Reference ref_112 Reference ref_113 Reference ref_114 Reference ref_115 Reference ref_116 Reference ref_117 Reference ref_118 Reference ref_119 Reference ref_120 Reference ref_121 Reference ref_122 Reference ref_123 Reference ref_124 |
| 37 | Reference ref_125 Reference ref_126 Reference ref_127 Reference ref_128 Reference ref_129 Reference ref_130 Reference ref_131 Reference ref_132 Reference ref_133 Reference ref_134 Reference ref_135 Reference ref_136 Reference ref_137 Reference ref_138 Reference ref_139 Reference ref_140 Reference ref_141 Reference ref_142 Reference ref_143 |
| 38 | Reference ref_144 Reference ref_145 Reference ref_146 Reference ref_147 Reference ref_148 Reference ref_149 Reference ref_150 Reference ref_151 Reference ref_152 Reference ref_153 Reference ref_154 Reference ref_155 Reference ref_156 Reference ref_157 Reference ref_158 Reference ref_159 Reference ref_160 |
